A blockbuster week that sees the return of the expanded UEFA Champions League ends with a mouthwatering, top-of-the-table Premier League encounter between Manchester City and Arsenal.
Monday
The first match of the week comes in the Premier League Cup for Under-21 sides, as Bristol City host Bromley at 19:00 BST.
Unai Emery will be speaking to the media ahead of Aston Villa's UEFA Champions League League match at reigning Swiss champions Young Boys the following day.
Arne Slot will also share team news and his thoughts ahead of Liverpool's Champions League tie at AC Milan, while a host of Premier League managers will hold press conferences for their EFL Cup fixtures.
Tuesday
After the conclusion of the qualifiers and playoffs, the revamped Champions League begins in earnest with the first league-phase fixtures of the campaign. The competition now consists of a single 36-team league, with all teams playing eight matches against eight different clubs to determine who reaches the knockout phase.
Huge excitement surrounds Villa’s first Champions League match at 17:45 BST against Young Boys. Villa last played in the European Cup 41 years ago, having won the competition the season before.
The other English involvement sees Liverpool face AC Milan at 20:00 BST. The match marks the Reds' Champions League return after a season out of Europe’s premier competition.
Pep Guardiola will provide the latest from Man City's camp as they prepare to face Inter Milan at home in the Champions League.
On the domestic front the EFL Cup resumes at the third round stage. Manchester United host League One side Barnsley at 20:00 BST, while Everton welcome Southampton at 19:45 BST. Fulham, Brentford and Crystal Palace are also in action.
Premier League Under-21 sides will be taking to the pitch. West Ham United, Everton, Fulham and Brighton & Hove Albion are among those playing in the Bristol Street Motors Trophy, while Wolverhampton Wanderers feature in the Premier League Cup, and Tottenham Hotspur and Palace play in the Premier League International Cup.
Wednesday
The Champions League continues with a rematch of the 2022/23 final when Man City welcome Inter Milan to the Etihad Stadium at 20:00 BST.
Three more Premier League clubs are in EFL Cup action, with Brighton hosting Wolves at 19:45 BST, and Spurs travelling to Coventry City at 20:00 BST.
Sunderland’s youngsters face Borussia Monchengladbach in the Premier League International Cup.
The last Champions League press conference takes place, with Mikel Arteta speaking ahead of Arsenal's away tie to Atalanta.
Thursday
The expansion of the Champions League means the tournament extends into a rare Thursday, with Arsenal travelling to Italy to face Atalanta at 20:00 BST.
A number of Premier League managers will give team news and player fitness updates at their pre-match press conferences ahead of the weekend.
Friday
The remaining Premier League managers will speak to the media before their weekend fixtures.
Premier League 2 returns with five fixtures, including Brighton’s trip to Nottingham Forest. Coventry host Hull City in the Premier League Cup.
Saturday
The Fantasy Premier League deadline for Gameweek 5 is at 11:00 BST.
A total of eight top-flight matches are scheduled, and the London derby between West Ham and Chelsea gets the Matchweek 5 action under way at 12:30 BST.
Villa welcome Wolves in a west midlands derby that is one of six 15:00 BST fixtures including Liverpool at home to AFC Bournemouth where the Reds could move top of the table - albeit briefly, before Sunday’s top-two showdown - if they win by a convincing margin. Leicester City face Everton and Southampton host Ipswich Town, with all four clubs seeking their first league win of the season.
The day’s late kick-off sees Palace welcome Man United to Selhurst Park at 17:30 BST. The Eagles are still without a win, while United are looking to build on their 3-0 win at Southampton last weekend.
Premier League fans based in the United States can enjoy the entire weekend’s action at the 10th Premier League Mornings Live Fan Festival, taking place in Chicago. The free two-day event will feature live match screenings, special guests, plus the NBC Sports studio team of host Rebecca Lowe and analysts Robbie Earle, Robbie Mustoe and Tim Howard broadcasting from the event.
Meanwhile, the local derby between Man United and Man City at 12:00 BST is the pick of four Premier League 2 ties.
Sunday
Aside from the top three clubs going into the weekend, Brighton and Nott'm Forest are the only other unbeaten sides in the Premier League so far this season. They meet at the Amex Stadium at 14:00 BST, with both looking to maintain their unbeaten start.
The weekend concludes at 16:30 BST with the biggest match of the campaign so far, when Man City host Arsenal in a contest that could have a major impact on the title race, even at this early stage.
Only two points separated the two teams in the final standings last season, and they have both continued to make the running in the opening weeks of the 2024/25 campaign. Arsenal, however, have not triumphed at the Etihad Stadium for almost a decade.
The last Premier League 2 fixture of the week sees Everton host Sunderland at 15:00 BST.
