Joao Moutinho scored a late winner as Wolverhampton Wanderers inflicted Manchester United's first defeat under Ralf Rangnick with a 1-0 victory at Old Trafford.
Phil Jones, making his first Premier League appearance for Man Utd in 712 days, made an impact with his first touch as he headed Francisco Trincao's dangerous cross clear.
That set the tone for a first half in which Wolves racked up 14 shots - a club record in the Premier League.
Bruno Lage's side were frustrated by David De Gea, who denied Daniel Podence and Ruben Neves with excellent saves before Jones brilliantly stopped Nelson Semedo's 45th-minute ball from reaching Neves.
United responded following the introduction of Bruno Fernandes on the hour-mark and the substitute hit the woodwork seven minutes later.
Romain Saiss also clipped the bar for Wolves with a 75th-minute free-kick before Moutinho picked up Jones's headed clearance and drove a low shot into the bottom corner eight minutes from time.
Defeat leaves Man Utd seventh on 31 points, four points behind fourth-placed Arsenal and with a match in hand.
Their first Premier League win at Old Trafford moves Wolves up to eighth, three points behind the Red Devils.
See: Man Utd report | Wolves report
Next fixtures
Man Utd: 15 Jan v Aston Villa (A)
Wolves: 15 Jan v Southampton (H)
Match officials
Referee: Mike Dean. Assistants: Darren Cann, Eddie Smart. Fourth official: Robert Jones. VAR: Andre Marriner. Assistant VAR: Gary Beswick.
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