There are some key contests lined up at both ends of the table in a mouthwatering Matchweek 32.
The race for European qualification features heavily in the opening fixture as Everton host Tottenham Hotspur on Friday.
In-form West Ham United then look to maintain their top-four spot when they visit fourth-from-bottom Newcastle United the next day, while defeat for Sheffield United at Wolverhampton Wanderers could spell relegation for the Blades this Matchweek.
On Sunday local pride is at stake along with crucial points when second-from-bottom Fulham visit Arsenal before, while on Tuesday Chelsea will look to boost their top-four prospects at home to a Brighton & Hove Albion side still needing points at the bottom end of the table.
The following day Pep Guardiola's Man City aim to move one step closer to the Premier League title when they visit Aston Villa, before the Matchweek concludes on Thursday as West Bromwich Albion look to boost their hopes of a "great escape" at Leicester City, who are themselves pushing for a European place.
Here's when and how you can watch those matches and many others on TV, or by streaming through NBC Sports.
TV Info - Broadcasters
The last four meetings between these sides at Goodison Park in all competitions have produced 22 goals, with eight for Everton and 14 for Spurs.
Where to watch: Watch on NBC Sports
TV Info - Broadcasters
West Ham are unbeaten in all 22 of their matches against bottom-half sides since David Moyes returned to the club as manager (W14 D8).
Where to watch: Watch on NBC Sports
TV Info - Broadcasters
Sheff Utd are 18 points from safety and with only 21 points available in their final seven matches, the Blades could be relegated this weekend if they are unable to win and other results go against them.
Where to watch: Watch on Peacock
TV Info - Broadcasters
Fulham are hoping for their first win at Arsenal in any competition (D5 L24).
Where to watch: Watch on NBC Sports
TV Info - Broadcasters
Manchester United are looking to win five consecutive Premier League matches for the first time since they won their first six under manager Ole Gunnar Solskjær in January 2019.
Where to watch: Watch on NBC Sports
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Fesh from their stunning 2-1 win at Manchester City, Leeds United are looking for only their second win in 12 home matches against Liverpool in all competitions (D3 L7). Their last victory was a 4-3 triumph in November 2000 when Mark Viduka scored all four goals for them.
Where to watch: Watch on NBC Sports
TV Info - Broadcasters
Brighton have lost 12 of their last 13 matches against Chelsea in all competitions, conceding 29 goals and scoring four.
Where to watch: Watch on Peacock
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Son Heung-min netted four goals, all set up by Harry Kane, as Spurs recorded a win 5-2 at Southampton when the sides met earlier this season.
Where to watch: Watch on Peacock
TV Info - Broadcasters
Since a 3-2 Premier League victory at Villa Park in September 2013, Villa are winless in their last 10 meetings with Man City in all competitions (D1 L9).
Where to watch: Watch on NBC Sports
TV Info - Broadcasters
The home side have never won in nine previous PL meetings between Leicester and West Brom.
Where to watch: Watch on NBC Sports