Ahead of Matchweek 5's Premier League fixtures, here are the standout facts on each match.
Click on the fixtures to see head-to-head records, past meetings and form guides.
Saturday, 15 September
Tottenham Hotspur v Liverpool
Matches featuring these two teams have had 22 penalties, more than any other in the competition's history.
AFC Bournemouth v Leicester City
Leicester striker Jamie Vardy returns from suspension and is the Foxes' main man for away goals in the PL, scoring nine of their last 17 on the road
Chelsea v Cardiff City
Pedro could make his 100th Premier League appearance in this match and is in a rich vein of form. Chelsea's Spaniard has scored three goals his last four league matches, matching his goal tally from his previous 26 fixtures.
Huddersfield Town v Crystal Palace
Crystal Palace have enjoyed their top-flight trips to Huddersfield Town. The Eagles have won all three matches there, keeping a clean sheet on each occasion.
Manchester City v Fulham
Man City last lost a Premier League home match to a promoted team more than 11 years ago, against Reading in February 2007 (pictured, above). They have since won 29 and drawn four.
Newcastle United v Arsenal
Arsenal have won two of their last three away Premier League matches and are looking to claim consecutive away league victories for the first time since May 2017.
Watford v Manchester United
Should Romelu Lukaku score in this fixture he will have reached 20 PL goals for Man Utd in only 39 matches. Only three players have done so in fewer: Ruud van Nistelrooy (26 matches), Robin van Persie (32) and Dwight Yorke (34).
Sunday, 16 September
Wolverhampton Wanderers v Burnley
Burnley have never won a Premier League away match against promoted opposition (W0 D6 L4). They suffered a 2-0 defeat at Wolves in December 2009 (pictured, above).
Everton v West Ham United
Everton have won more Premier League matches (24) and scored more goals (80) against West Ham than they have against any other team.
Monday, 17 September
Southampton v Brighton
Glenn Murray has good memories of facing Southampton, scoring in both Premier League meetings with them last season, as each match ended 1-1.
